Methods of using sustained release aminopyridine compositions

Details Methods of using sustained release aminopyridine compositions Methods of using sustained release aminopyridine compositions

A - Human Necessities

61

K

A61K 31/44 (2006.01)

Patent

CA 2562277

A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

Composition pharmaceutique comprenant une dose thérapeutiquement efficace d'une aminopyridine dispersée dans une matrice de libération, comprenant, par exemple, une composition pouvant se présenter sous la forme d'une préparation stable à libération soutenue, en comprimé par exemple, qui procure, après administration à un patient, une niveau de plasma d'aminopyridine thérapeutiquement efficace pendant environ 12 heures, et utilisation de cette composition pour le traitement de diverses affections neurologiques, dont la sclérose en plaques. L'invention concerne également une méthode de sélection d'individus en fonction de leur réponse à un traitement, notamment l'identification d'individus répondant à un traitement au moyen d'une composition de fampridine à libération soutenue.

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