Treating a tumor or the like with electric fields at...

A - Human Necessities – 61 – N

Patent

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A61N 1/32 (2006.01)

Patent

CA 2594231

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results are obtained when the field is sequentially imposed in different directions. The field may also be rotated through 360~ by applying AC waveforms with different phases to the electrodes.

L'invention concerne les cellules se trouvant dans les étapes anaphase ou télophase finales de la division cellulaire, sensibles à la détérioration par des champs électriques c.a. présentant des caractéristiques de fréquence et d'intensité de champ. La destruction sélective des cellules se divisant rapidement peut ainsi être accomplie en imposant un champ électrique c.a. dans une zone cible sur une longue durée. Certaines cellules se divisant lors de l'application du champ sont endommagées, mais les cellules ne se divisant pas ne sont pas endommagées. Ce processus entraîne la détérioration sélective des cellules se divisant rapidement, telles que les cellules tumorales, mais ne détériore pas les cellules normales ne se divisant pas. La vulnérabilité des cellules se divisant étant fortement associée à l'alignement entre l'axe long des cellules se divisant et les lignes de force du champ électrique, des résultats améliorés sont obtenus lorsque le champ est imposé de manière séquentielle dans différentes directions. Le champ peut également tourner à 360° par application de formes d'ondes c.a. de différentes phases sur les électrodes.

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