Fugetactic proteins, compositions and methods of use

Details Fugetactic proteins, compositions and methods of use Fugetactic proteins, compositions and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2532035

This invention relates to compositions and methods that modulate the movement of cells with migratory capacity. More specifically, the invention relates to compositions and methods for promoting migratory movement, fugetaxis, of cells from a specific site in a subject. The foregoing are useful, inter alia,in the treatment of conditions characterized by a need to promote migratory cell movement away from specific sites in a subject. Specific sites include sites of inflammation, infection, an autoimmune reaction, a tumor and a transplanted organ or tissue.

L'invention concerne des compositions et des procédés qui modulent le mouvement de cellules à activité migratoire. Plus particulièrement, l'invention concerne des compositions et des procédés permettant de promouvoir le mouvement migratoire, (<=fugetaxis>=, chimio-répulsion), de cellules depuis un site spécifique chez un sujet. Les compositions et procédés de l'invention sont utiles, entre autres, dans le traitement d'états caractérisés par la nécessité de promouvoir le mouvement migratoire de cellules à l'opposé de sites spécifiques chez un sujet. Parmi les sites spécifiques, on peut citer des sites d'inflammation, d'infection, d'une réaction auto-immune, d'une tumeur et d'un organe ou tissu transplanté.

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