Anti-cd3 antibodies and methods of use thereof

Details Anti-cd3 antibodies and methods of use thereof Anti-cd3 antibodies and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2569509

The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR~s), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

La présente invention concerne des anticorps dirigés contre l'antigène CD3 et leurs utilisations. Notamment, cette invention a trait à des anticorps monoclonaux entièrement humains dirigés contre CD3. Ladite invention a également pour objet le codage de séquences de nucléotides et des séquences d'acides aminés contenant des molécules d'immunoglobines à chaînes lourde et légère, plus spécifiquement, des séquences correspondant à des séquences à chaînes lourde et légère contigües qui étalent les régions de structure et/ou les régions de détermination de la complémentarité (CDR's), particulièrement de FR1 par FR4 ou de CDR1 par CDR3. L'invention concerne aussi des hybridomes ou d'autres lignées cellulaires exprimant de telles molécules d'immunoglobines et des anticorps monoclonaux.

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