Antifolate agent combinations in the treatment of cancer

Details Antifolate agent combinations in the treatment of cancer Antifolate agent combinations in the treatment of cancer

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/13 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2674075

Compositions and methods useful in the treatment of certain cancers. The methods include administering, to a patient receiving an antifolate anticancer agent, methoxyamine administered in an amount sufficient to enhance or increase the effect of the antifolate anticancer agent. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.

L'invention concerne des compositions et des méthodes utiles dans le traitement de certains cancers. Ces méthodes consistent à administrer à un patient recevant un agent anticancéreux à base d'antifolates de la méthoxyamine en quantité suffisante pour améliorer ou augmenter l'effet de l'agent anticancéreux à base d'antifolates. La présente invention est fondée, en partie, sur le fait que certaines molécules ciblant des lésions abasiques ou des sites AP de l'ADN améliorent, augmentent ou renforcent l'efficacité chimiothérapeutique de certains agents anticancéreux.

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