Devices and methods comprising a serum albumin - target...

Details Devices and methods comprising a serum albumin - target... Devices and methods comprising a serum albumin - target...

G - Physics

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G01N 33/543 (2006.01) G01N 33/532 (2006.01) G01N 33/569 (2006.01) G01N 33/576 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2269087

Improved methods and compositions for the detection and diagnosis of disease utilizing a target antigen complexed with a serum albumin to provide a conformationally changed target antigen. Also, antibodies, including both IgM and IgG antibodies as well as all other forms of antibodies, specific for serum albumin and/or for the conformationally changed target antigens, as well as methods for purifying each using immunologic methods such as affinity columns. Enhanced methods and compositions comprising a target antigen complexed with a serum albumin for the induction of immune responses in an animal, as well as enhanced vaccination of such an animal. Further, a preferred buffer, TNSCN, comprised of Tris-HC1, NaC1, and NaSCN, typically at a pH of about 7.4 ~ 0.2.

Procédés et compositions améliorés servant à effectuer la détection et le diagnostic de maladies au moyen d'un complexe constitué par de l'albumine sérique et un antigène ciblé, ce qui permet d'obtenir un antigène ciblé dont la conformation a été modifiée. Anticorps comprenant à la fois des anticorps d'IgM et de IgG, ainsi que toutes les autres formes d'anticorps, spécifiques pour l'albumine sérique ou pour les antigènes ciblés à conformation modifiée, ainsi que procédés servant à purifier chacun au moyen de méthodes immunologiques, telles que des colonnes d'affinité. Procédés et compositions améliorés contenant un antigène ciblé mis en complexe avec une albumine sérique afin de provoquer une réaction immune chez un animal, ainsi que vaccination améliorée de cet animal. De plus, tampon préféré, TNSCN, composé de Tris-HCl, NaCl et NaSCN, normalement à un pH d'environ 7,4+/-0,2.

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