C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2004592
ABSTRACT This invention relates to a method for the isolation of trophoblast (placental) sells from the blood of a pregnant mammal so as to provide the essential starting material, namely cells derived from the fetus, to enable genetic and/or biochemical information about the fetus to be obtained. In particular, this invention relates to the use of monoclonal antibodies specific for membrane protein markers on mammalian trophoblasts to isolate trophoblast cells from maternal blood. These cells may then be used to obtain fetal genetic and/or biochemical information early in pregnancy. The present invention is particularly relevant for detecting human fetal abnormalities.
Hawes Catherine S.
Mueller Utz W.
Flinders Technologies Pty Ltd.
Kirby Eades Gale Baker
LandOfFree
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