C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A01N 57/18 (2006.01) C07K 14/445 (2006.01) C12N 9/04 (2006.01) C12N 9/10 (2006.01) C12N 9/88 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/527 (2006.01) C12Q 1/533 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2328157
The invention relates to a method for identifying chemical active agents which are suitable for treating infectious diseases caused by single- or multi- celled parasites. According to the method, proteins which form part of the 1- desoxy-d-xylulose-5-phosphate metabolic pathway or derivatives thereof which act in the same way are brought into contact with the active agents being tested for their effectiveness against parasites and those active agents which inhibit the proteins or their derivatives are selected. The invention also relates to the active agents which are identified and to their use for producing medicaments for treating parasitic infections.
L'invention concerne un procédé permettant de trouver des principes actifs chimiques adaptés au traitement d'infections dues à des parasites monocellulaires ou pluricellulaires. Ce procédé consiste à mettre en contact des protéines qui participent à la voie de métabolisme du 1-désoxy-D-xylulose-5-phosphate, ou de leurs dérivés d'action identique avec les principes actifs dont on veut examiner l'action vis-à-vis des parasites. Ce procédé consiste ensuite à sélectionner les principes actifs qui inhibent les protéines ou leurs dérivés. L'invention concerne également les principes actifs trouvés et destinés à la production de médicaments efficaces contre les infections parasitoses.
Hassan Jomaa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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