Compounds with growth hormone releasing properties

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/06 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/087 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 7/02 (2006.01) C07K 9/00 (2006.01) C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2179598

Synthetic peptides of the general formula A-B-C-D-E-(F)p, wherein p is 0 or 1, with an improved resistance to proteolytic degradation by enzymes due to the substitution of an amide bond (-CONH-) with aminomethylene (-CH2NH-) or by introducing an N-aralkyl glycine and a pharmaceutical composition for stimulating the release of growth hormone from the pituitary.

Peptides synthétiques représentés par la formule générale A-B-C-D-E-(F)¿p?, dans laquelle p est 0 ou 1 et présentant une résistance améliorée à la dégradation protéolytique provoquée par des enzymes sous l'effet de la substitution d'une liaison amide (-CONH-) par aminométhylène (-CH¿2?NH-) ou par l'introduction d'une N-aralkyle glycine et composition pharmaceutique servant à stimuler la libération de l'hormone de croissance de l'hypophyse.

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