Sulfonamide-substituted fused 7-membered ring compounds,...

Details Sulfonamide-substituted fused 7-membered ring compounds,... Sulfonamide-substituted fused 7-membered ring compounds,...

C - Chemistry, Metallurgy

07

D

C07D 313/08 (2006.01) A61K 31/18 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07C 311/07 (2006.01) C07D 221/04 (2006.01) C07D 223/16 (2006.01) C07D 337/08 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2230349

Sulfonamide-substituted fused 7-membered ring compounds, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I, (see Fig.I) in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the claims, their preparation and their use, in particular in pharmaceuticals. The compounds effect the potassium channel or the IKs channel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.

Composés à noyau condensé de 7 atomes substitué par un sulfonamide, procédés pour leur préparation, leur utilisation comme médicament ou produit diagnostique, et préparations pharmaceutiques comprenant ces derniers. La présente invention concerne des composés de formule I, (voir Fig. I) où X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) et R(5) ont les significations indiquées dans les revendications, leur préparation et leur utilisation, en particulier dans les produits pharmaceutiques. Ces composés agissent sur le canal de potassium ou le canal IKs ouvert par l'adénosine-monophosphate cyclique (AMPc) et ont une valeur exceptionnelle comme composés pharmaceutiques actifs, par exemple pour la prévention et le traitement des maladies cardio-vasculaires, en particulier les arythmies, pour le traitement des ulcères de la région gastro-intestinale ou pour le traitement des affections diarrhéiques.

Affiliated with

Also associated with

Rating

Sulfonamide-substituted fused 7-membered ring compounds,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfonamide-substituted fused 7-membered ring compounds,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonamide-substituted fused 7-membered ring compounds,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1720467