3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives...

Details 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives... 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives...

C - Chemistry, Metallurgy

07

D

C07D 241/28 (2006.01) A61K 31/497 (2006.01) A61P 11/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2723938

A compound of Formula (I) in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

L'invention porte sur un composé de Formule (I) sous forme libre ou de sel ou de solvate, dans laquelle formule R1, R2, R3, R4, R5, R6, R7, R8 et R9 ont les significations telles qu'indiquées dans la description, lequel composé est utile pour le traitement de maladies qui sont sensibles au blocage du canal sodique épithélial. L'invention porte également sur des compositions pharmaceutiques qui contiennent les composés et sur des procédés pour la fabrication des composés.

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