C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2269634
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention concerne un ensemble de séquences d'ARN contiguës et se chevauchant partiellement, ainsi que des polypeptides codés par celles-ci, dénommées BS 106 et transcrites à partir de tissu mammaire. Ces séquences peuvent être utilisées pour le dépistage, le diagnostic, l'évaluation du stade, la surveillance, le pronostic, la prévention ou le traitement concernant des pathologies mammaires telles qu'un cancer du sein, ou bien pour la détermination de la prédisposition d'un individu à une telle pathologie. L'invention concerne également des anticorps qui se fixent spécifiquement au polypeptide ou à la protéine codés par BS 106, ainsi que des agonistes ou des inhibiteurs qui empêchent l'action du polypeptide codé par BS 106 spécifique du tissu concerné, ces molécules pouvant être utilisées pour la thérapie de pathologies, tumeurs ou métastases mammaires.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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