Process for production of avermectins and cultures therefor

Details Process for production of avermectins and cultures therefor Process for production of avermectins and cultures therefor

C - Chemistry, Metallurgy

12

P

C12P 19/62 (2006.01) C12N 1/20 (2006.01) C12N 15/03 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2131284

This invention relates to Streptomyces avermitilis lacking branched-chain amino acid transaminase activity, branched-chain 2-oxo acid biosynthetic activity and, optionally and preferably, avermectin B-O-methyl transferase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins from branched-chain fatty acid or branched-chain 2-oxo acid precursors. Such avermectins are useful as parasiticides.

La présente invention concerne une souche de Streptomyces avermitilis privée de l'activité de la transaminase des acides aminés à chaîne ramifiée, de l'activité biosynthétique de l'acide 2-oxo à chaîne ramifiée et, facultativement et préférablement, de l'activité de l'avermectine B-O-méthyltransférase, des méthodes pour la préparation de ce produit et son utilisation pour produire des avermectines naturelles et non naturelles à partir d'acides gras à chaîne ramifiée ou de précurseurs de l'acide 2-oxo à chaîne ramifiée. Ces avermectines sont utiles comme parasiticides.

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