Compounds for treating aids and other diseases

Details Compounds for treating aids and other diseases Compounds for treating aids and other diseases

C - Chemistry, Metallurgy

07

C

C07C 235/34 (2006.01) A61K 31/165 (2006.01) A61K 47/48 (2006.01) A61P 31/18 (2006.01) A61P 37/00 (2006.01) C07C 233/22 (2006.01) C07D 209/18 (2006.01) C08G 65/333 (2006.01)

Patent

CA 2560922

The present invention provides methods for treating Acquired Immunodeficiency Syndrome (AIDS) and other viral diseases and Human Immunodeficiency Virus (HIV) related infections by administering one or more compounds of formula I: wherein: the dotted line represents a single or a double bond; and R1 and R2 are the same or different and independently of each other represent - CH2OH, - CH2OR4, -CH(OH)CH3, -CH(OR4)CH3 or a group represented by the formula: or salts or hydrates thereof in a carrier which minimizes micellar formation or van der Waals attraction of molecules of said compound. The invention also provides S enantiomeric forms of such compounds which possess the ability to inhibit cell growth whilst being of low toxicity to such cells and methods of making such compounds.

L'invention concerne des méthodes permettant de traiter le syndrome d'immunodéficience acquise (SIDA) et d'autres maladies virales et infections associées au VIH (virus de l'immunodéficience humaine) par l'administration d'un ou de plusieurs composés représentés par la formule I, dans laquelle la ligne pointillée représente une liaison unique ou double ; et R1 et R2 sont identiques ou différents et représentent indépendamment l'un de l'autre - CH2OH, -CH2OR4, -CH(OH)CH3, -CH(OR4)CH3 ou un groupe représenté par la formule II, III ou IV, ou des sels ou des hydrates desdits composés, dans un excipient qui minimise la formation micellaire ou une attraction Van der Waals de molécules dudit composé. L'invention concerne également <I>S</I> formes énantiomères desdits composés, lesquelles formes ont la capacité d'inhiber la croissance cellulaire tout en présentant une faible toxicité par rapport à ces cellules ainsi que des méthodes de fabrication de ces composés.

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