Treatment of proliferative disorders using antibodies to psma

Details Treatment of proliferative disorders using antibodies to psma Treatment of proliferative disorders using antibodies to psma

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2700410

Methods of treating cancer in a patient are provided. In some embodiments the method comprises administering an antibody that is capable of binding to the extracellular domain of PSMA. In some embodiments, the method comprises restricting folate intake by the patient. Methods of monitoring cancer therapy are provided as well as kits for treating cancer and kits for monitoring cancer therapy.

L'invention concerne des procédés de traitement du cancer chez un patient. Dans certains modes de réalisation, le procédé comprend l'administration d'un anticorps capable de se lier au domaine extracellulaire du PSMA. Dans certains modes de réalisation, le procédé comprend la limitation de l'absorption de folate par le patient. Des procédés de contrôle de la thérapie du cancer sont prévus ainsi que des nécessaires de traitement du cancer et des nécessaires de contrôle de la thérapie du cancer.

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