Aptamer against midkine and use thereof

Details Aptamer against midkine and use thereof Aptamer against midkine and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 38/00 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2669523

It is intended to provide a high-quality aptamer against midkine. An aptamer having an inhibitory activity against midkine; a complex comprising an aptamer having a binding activity or an inhibitory activity against midkine and a functional substance (such as an affinity substance, a labeling substance, an enzyme, a drug delivery medium or a drug); a pharmaceutical, a cell migration inhibitor, a diagnostic agent and a labeling agent comprising an aptamer having a binding activity or an inhibitory activity against midkine, or a complex containing the aptamer and a functional substance; and the like.

L'invention porte sur un aptamère de qualité élevée contre la midkine. L'invention porte sur un aptamère ayant une activité inhibitrice à l'encontre de la midkine ; sur un complexe comprenant un aptamère ayant une activité de liaison ou une activité inhibitrice à l'encontre de la midkine et une substance fonctionnelle (telle qu'une substance d'affinité, une substance de marquage, une enzyme, un milieu d'administration de médicament ou un médicament) ; sur un produit pharmaceutique, un inhibiteur de migration cellulaire, un agent de diagnostic et un agent de marquage comprenant un aptamère ayant une activité de liaison ou une activité inhibitrice contre la midkine, ou un complexe contenant l'aptamère et une substance fonctionnelle ; et similaires.

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