Therapeutic targets and medicaments involving p230/golgin-245

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61P 29/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2707107

The present invention relates generally to the field of cell biology and in particular the cellular processes surrounding inflammation. Even more particularly, the present invention provides targets for medicaments useful in reducing levels of TNF--alpha, an extracellular pro-inflammatory mediator. The medicaments are therefore useful in modulating inflammatory responses. Model inflammatory disease systems also form part of the present invention.

La présente invention concerne d'une manière générale le domaine de la biologie cellulaire et, en particulier, les processus cellulaires entourant une inflammation. Encore plus particulièrement, la présente invention porte sur des cibles pour des médicaments utiles dans la réduction de taux de TNF-alpha, un médiateur pro-inflammatoire extracellulaire. Les médicaments sont par conséquent utiles dans la modulation des réponses inflammatoires. Des systèmes modèles de maladie inflammatoire font également partie de la présente invention.

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