Systems and methods for polymer characterization

Details Systems and methods for polymer characterization Systems and methods for polymer characterization

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 15/12 (2006.01)

Patent

CA 2708782

Techniques for controlling the position of a charged polymer (112) inside a nanopore (105) are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well (114) inside the nanopore, whereby the electrostatic potential well controls the position of the linear charged polymer inside the nanopore. By sequentially locking each monomer unit in the potential well (114), nanopore sequencing of DNA with single base resolution can be achieved.

L'invention concerne des techniques pour réguler la position d'un polymère chargé (112) à l'intérieur d'un nanopore (105). Par exemple, l'une des techniques comprend l'utilisation d'une commande électrostatique pour positionner un polymère chargé linéaire à l'intérieur d'un nanopore, et la création d'un puits de potentiel électrostatique (114) à l'intérieur du nanopore, le puits de potentiel électrostatique régulant ainsi la position du polymère chargé linéaire à l'intérieur du nanopore. En bloquant successivement chaque motif monomère dans le puits de potentiel (114), il est possible d'effectuer le séquençage par nanopores de l'ADN avec une résolution d'une seule base.

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