C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/42 (2006.01) A61K 31/155 (2006.01) A61K 31/18 (2006.01) A61K 31/395 (2006.01) C07C 311/16 (2006.01) C07C 311/29 (2006.01) C07C 311/47 (2006.01) C07C 317/44 (2006.01) C07C 317/46 (2006.01) C07C 317/48 (2006.01) C07C 323/44 (2006.01) C07C 323/65 (2006.01) C07D 211/70 (2006.01) C07D 295/155 (2006.01)
Patent
CA 2106613
The invention relates to benzoylguanidines of the formula I (see formula I) where R(1) or R(2) ins R(3)-S(O)n- or R(4)R(5)N-O2S- and the other substituent R(1) or R(2) in each case is H, OH, F, Cl, Br, I, alkyl, alkoxy, benzyloxy or phenoxy, R(3)-S(O)n or R(4)R(5)N- or 3,4-dehydropiperidine and R(3) is alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(4) and R(5) are alkyl or phenylalkyl or phenyl, and in which R(4) and R(5) can also together be a C4-C7-chain, and in which R(4) and R(5), together with the nitrogen atom to which they are bonded, can be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where n is zero, 1 or 2 and their pharmaceutically tolerable salts are excellent antiarrhythmics. They are obtained by a process in which compounds of the formula II (see formula II) in which X is a leaving group which can be easily substituted nucleophilically, are reacted with guanidine.
Albus Udo
Englert Heinrich
Kleemann Heinz-Werner
Lang Hans-Jochen
Scholz Wolfgang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
Sanofi-Aventis Deutschland Gmbh
LandOfFree
Benzoylguanidines, process for their preparation, their use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzoylguanidines, process for their preparation, their use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoylguanidines, process for their preparation, their use... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1723147