Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/280

C07D 233/64 (2006.01) A61K 31/395 (2006.01) A61K 38/06 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/08 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2012901

RAN 4019/108 Abstract The compounds of the formula Image I wherein A, R1, R2, R3 and R4 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.

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