New tumour markers and biological applications thereof

G - Physics – 01 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

G01N 33/574 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2473788

The application relates to the use of at least one protein selected from the group consisting of FADD proteins and phosphorylated p38-MAPK, as a marker for absence of in vivo tumour. This use may further be complemented by the use of the FasL protein as a marker for presence of in vivo tumour. The (respective) amount(s) of FADD proteins and phosphorylated p38-MAPK indeed decrease, sometimes up to zero, with tumour development, while FasL expression is gained. FADD proteins are secreted from out of the tumour cells into their extracellular environment. A low cellular amount and a high extracellular amount of FADD proteins are prognostic of resistance to chemotherapy.

L'invention concerne l'utilisation d'au moins une protéine sélectionnée dans le groupe constitué de protéines FADD et p38-MAPK phosphorylées, comme marqueur d'absence de tumeur in vivo. Cette utilisation peut, de plus, être complétée par l'utilisation d'une protéine FasL comme marqueur de présence de tumeur in vivo. La/les quantité(s) respective(s) de protéines FADD et p38-MAPK phosphorylées décroît effectivement, parfois jusqu'à zéro, avec le développement de la tumeur, alors que l'expression de FasL est augmentée. Des protéines FADD sont sécrétées à partir des cellules tumorales à l'intérieur de leur environnement extracellulaire. Une faible quantité cellulaire et une quantité extracellulaire élevée de protéines FADD permettent de pronostiquer une résistance à la chimiothérapie.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

New tumour markers and biological applications thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New tumour markers and biological applications thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New tumour markers and biological applications thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1723501

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.