A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/435 (2006.01)
Patent
CA 2335134
This invention is directed to pharmaceutical combination compositions and methods containing (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)- 5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N-(2-(3a(R)-benzyl-2-methyl-3-oxo-2,3, 3a, 4,6,7-hexahydro- pyrazolo-[4,3-c]pyridin-5-yl)-1(R)-benzyloxymethyl-2-oxo-ethyl)-isobutyramide or a pharmaceutically acceptable salt thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass, frailty and low muscle mass.
La présente invention concerne des compositions pharmaceutiques associées renfermant (-)-cis-6-phényl-5-(4-(2-pyrrodine-1-yl-éthoxy)-phényl)-5,6,7,8-térahydronaphtalène-2-ol ou un sel pharmaceutiquement acceptable de ces compositions et 2-amino-N-(2-(3a (R)-benzyl-2-méthyl-3-oxo-2,3, 3a ,4,6,7-hexahydro-pyrazolo-[4,3-c]pyridine-5-yl)-1(R)-benzyloxyméthyl-2-oxo-éthyl)-isobutyramide ou un sel pharmaceutiquement acceptable, ainsi que des méthodes d'utilisation de telles compositions ou de préparations renfermant de telles compositions. Ces compositions sont utiles pour le traitement de la fragilité musculo-squelettique, notamment en cas d'ostéoporose, de fractures imputables à l'ostéoporose, de faible masse osseuse, de fragilité osseuse et de faible masse musculaire.
Ke Hua Zhu
Li Mei
Pan Lydia Codetta
Thompson David Duane
Pfizer Products Inc.
Smart & Biggar
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