Nickel-free hemoglobin and methods for producing such...

Details Nickel-free hemoglobin and methods for producing such... Nickel-free hemoglobin and methods for producing such...

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 38/42 (2006.01) C07K 1/36 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2166616

According to the present invention removal of nickel from a nickel-containing hemoglobin solution is accomplished by exposing the nickel-containing hemoglobin solution to a chelating agent, preferably a multidentate acetic acid based chelator such as EDTA. Methods are provided that allow obtaining essentially nickel-free hemoglobin from nickel-containing hemoglobin solutions, particularly hemoglobin solutions that result from large scale fermentation and/or purification.

Selon l'invention, pour extraire d'une solution d'hémoglobine le nickel qu'elle contient, ladite solution d'hémoglobine contenant du nickel est exposée à un agent chélatant, de préférence un chélateur à base d'acide acétique multicoordonné comme du EDTA. L'invention concerne des procédés permettant d'obtenir de l'hémoglobine sensiblement exempte de nickel, à partir de solutions d'hémoglobine contenant du nickel, notamment de solutions d'hémoglobine issues de fermentation et/ou de purification à grande échelle.

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