Polyprolyl inhibitors of cyclophilin

Details Polyprolyl inhibitors of cyclophilin Polyprolyl inhibitors of cyclophilin

A - Human Necessities

61

K

A61K 38/03 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2263828

This invention relates to neurotrophic low molecular weight, small molecule peptidic cyclophilin inhibitor compounds having an affinity for cyclophilin- type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

Cette invention a trait à des composés neurotrophiques de faible poids moléculaire et à molécule de taille réduite, inhibiteurs de la cyclophiline peptidique, ayant une affinité pour des immunophillines de type cyclophiline. Elle concerne également leur utilisation en tant qu'inhibiteurs de l'activité enzymatique liée à des protéines d'immunophilline, notamment de l'activité enzymatique de la peptidyl-prolyl isomérase ou de la rotamase.

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