A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/195 (2006.01) A61K 47/00 (2006.01) A61K 47/32 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/22 (2006.01)
Patent
CA 2325400
The present invention provides a pressure sensitive skin adhesive comprising: (a) a copolymer of one or more alkyl(meth)acrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers; (b) a mixture of penetration enhancers comprising: (i) an alkyl ester of an aliphatic monocarboxylic acid containing 1 to 5 carbon atoms in the alkyl group; (ii) an alkyl pyrrolidone and (iii) an alkane polyol; (c) a therapeutically effective amount of diclofenac or a pharmaceutically acceptable salt thereof. Further provided is a transdermal drug delivery device containing the pressure sensitive skin adhesive.
La présente invention concerne un adhésif autocollant pour la peau renfermant: a) un copolymère d'un ou plusieurs alkyl(méth)acrylates contenant 4 à 12 atomes de carbone dans le groupe alkyle, ainsi qu'un ou plusieurs monomères hydrophiles; b) un mélange d'activateurs de pénétration comprenant: i) un ester alkyle d'un acide monocarboxylique aliphatique, contenant 1 à 5 atomes de carbone dans le groupe alkyle, ii) une pyrrolidone alkyle, et iii) un polyol alcane; et c) une quantité thérapeutiquement efficace de diclofénac, ou d'un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également un dispositif d'apport médicamenteux transdermique, contenant l'adhésif autocollant pour la peau susmentionné.
Becker Anja N.
Coors Carsten
Effing Jochem J.
Minnesota Mining And Manufacturing Company
Robic
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