C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2267646
Disclosed is a novel protein designated platelet secretory transport protein (PSTP). PSTP occurs in platelets and binds to syntaxin. An isolated DNA encoding PSTP, vectors and cells containing the DNA, and PSTP specific antibodies are also disclosed. A PSTP antibody can be used to target a compound to an activated platelet in a mammal for diagnostic or therapeutic purposes. Also disclosed is an in vitro screening method for identifying a compound that inhibits PSTP-syntaxin binding, and an in vitro method for identifying a compound that inhibits PSTP gene expression.
L'invention concerne une nouvelle protéine désignée protéine de transport et de sécrétion pour les plaquettes (PSTP). PSTP apparaît dans les plaquettes et se fixe à syntaxine. L'invention concerne également un A D N isolé codant PSTP, des vecteurs et ces cellules contenant cet A D N et des anticorps spécifiques pour PSTP. On peut utiliser un anticorps anti-PSTP afin de cibler un composé vers une plaquette activée chez un mammifère à des fins diagnostiques ou thérapeutiques. Elle concerne, de plus, un procédé de recherche par criblage in vitro servant à identifier un composé inhibant la fixation de PSTP à syntaxine, ainsi qu'un procédé in vitro servant à identifier un composé inhibant l'expression du gène de PSTP.
Kirby Eades Gale Baker
President And Fellows Of Harvard College
LandOfFree
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