Novel proteins in enteroaggregative escherichia coli (eaec)...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 39/108 (2006.01) A61P 31/04 (2006.01) C07K 14/245 (2006.01) C07K 16/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2467691

Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five genes cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. The use of these novel proteins and their corresponding nucleotide sequences for diagnosis, therapy, and prevention of EAEC infections is also provided.

L'invention concerne de nouvelles protéines et leurs séquences nucléotidiques correspondantes dans Escherichia coli entéro-agregatif (EAEC). En particulier, Aap et l'agrégat de cinq gènes (aat) de la région de sonde AA du plasmide pAA de EAEC 042 ont été identifiés, séquencés et caractérisés. L'invention concerne également l'utilisation de ces nouvelles protéines et de leurs séquences nucléotidiques correspondantes pour le diagnostic, la thérapie et la prévention d'infections à EAEC.

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