Detection of alzheimer's disease and other diseases using a...

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G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01) G01N 33/60 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2125787

A method for diagnosing a neurological disease comprising detecting a neurological disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid is disclosed. In particular. a radioactively labeled photoaffinity probe is used to diagnose a neurological disease. For instance, Alzheimer's disease can be diagnosed by detecting a disease-specific protein having a molecular weight of about 42,000 daltons, i.e., glutamine synthetase.

Procédé permettant de diagnostiquer une maladie neurologique, et consistant à détecter une macromolécule marqueur biochimique et spécifique à une maladie neurologique, dans un échantillon de liquide céphalo-rachidien extrait. En particulier, une sonde à photoaffinité à marquage radioactif est utilisée pour diagnostiquer une maladie neurologique. La maladie d'Alzheimer, par exemple, peut être diagnostiquée par la détection d'une protéine spécifique par rapport à la maladie et d'un poids moléculaire de 42.000 daltons environ, en d'autres termes, la glutamine synthétase.

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