Anticonvulsant derivatives useful in treating neuropathic pain

Details Anticonvulsant derivatives useful in treating neuropathic pain Anticonvulsant derivatives useful in treating neuropathic pain

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2267945

The present invention describes a method for treating neuropathic pain comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of formula (I), wherein: X is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of formula (II), wherein R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring, particularly topiramate.

L'invention concerne un procédé pour le traitement de la douleur neuropathique, qui consiste à administrer à un mammifère souffrant de ladite affection, une dose thérapeutiquement efficace d'un composé de formule (I). Dans ladite formule (I), X représente CH2 ou oxygène; R1 représente hydrogène ou alkyle; et R2, R3, R4 et R5 représentent séparément hydrogène ou alkyle inférieur et, lorsque X est CH2, R4 et R5 peuvent être des groupes alcènes liés pour former un cycle benzène et, lorsque X est oxygène, R2 et R3 et/ou R4 et R5 peuvent représenter conjointement un groupe méthylènedioxy de formule générale (II). Dans la formule générale (II), R6 et R7 sont identiques ou différents et représentent oxygène, alkyle inférieur ou alkyle et sont liés pour former un cycle cyclopentyle ou cyclohexyle, en particulier du toporimate.

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