A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 19/00 (2006.01) G01N 33/574 (2006.01) G01N 33/84 (2006.01)
Patent
CA 2407548
The present invention discloses the use of PSP-94 for treating a patient suffering from hypercalcemia of malignancy. Prostate secretory protein of 94 amino acids (PSP- 94) is known to serve as prognostic marker in hormone-dependent prostate. In the current study the effect of PSP-94 on prostate cancer growth, metastases to the skeleton and hypercalcemia of malignancy was examined. A marked dose-dependent decrease in primary tumor volume was seen in experimental animals receiving PSP-94. Furthermore, while control animals routinely developed hypercalcemia due to PTHrP production, treatment with PSP-94 led to a near normalization of plasma calcium and a marked reduction in PTHrP production as determined by radioimmunoassay and immunohistochemistry. Results obtained demonstrate the ability of PSP-94 to be an effective treatment modality for prostate cancer. Furthermore, decrease in plasma PTHrP and calcium levels can serve as useful biochemical markers for monitoring the efficacy of this novel anti-tumor agent.
Newman Christopher
Panchal Chandra J.
Rabbani Shafaat Ahmed
Shukeir Nicholas
Ambrilia Biopharma Inc.
Fasken Martineau Dumoulin Llp
Procyon Biopharma Inc.
LandOfFree
Psp94: use for treatment of hypercalcemia and bone metastasis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Psp94: use for treatment of hypercalcemia and bone metastasis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Psp94: use for treatment of hypercalcemia and bone metastasis will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1724814