A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 31/00 (2006.01) A61K 31/7084 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07H 21/04 (2006.01) C12N 7/00 (2006.01)
Patent
CA 2621127
This invention provides novel methods of treating or alleviating neoplasms in a mammal and enhancing the efficacy of oncolytic viruses by using a combination of an oncolytic virus and an immunostimulant, comprising administering a reovirus to a host and enhancing an immune response by the addition of an immunostimulant such as a CpG oligodeoxynucleotide or at least one antigen of said virus that is delivered to a host by dendritic cells.
La présente invention concerne de nouveaux procédés permettant de traiter des néoplasmes ou de réduire leur prolifération chez un mammifère et de renforcer l~efficacité des virus oncolytiques en associant un virus oncolytique et un immunostimulant. Le traitement consiste à administrer un réovirus à un hôte et à renforcer une réponse immunitaire en ajoutant un immunostimulant tel que l~oligodéoxynucléotide CpG ou au moins un antigène dudit virus qui est transmis à un hôte par des cellules dendritiques.
Coffey Matthew C.
Thompson Bradley G.
Marks & Clerk
Oncolytics Biotech Inc.
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