Imidazolidinone derivative, acid-addition salt thereof, and...

Details Imidazolidinone derivative, acid-addition salt thereof, and... Imidazolidinone derivative, acid-addition salt thereof, and...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2172163

Imidazolidinone derivatives represented by a following general formula (1) or pharmacologically permissible acid addition salts with cholinergic activity (muscarine M1 activity) provide compounds useful for the therapy of senile dementia. (1) Image (wherein R denotes a lower alkyl group which may be substitut- ed by halogen, or the like, R1 and R2 denote identically or differently hydrogen atoms or lower alkyl groups, R3 denotes a formula Image (wherein R4 denotes a lower alkyl group which may be substi- tuted by halogen, or the like, q denotes 0 to 3, and R5 denotes a hydrogen atom or the like), m and n denote 0 to 3, p denotes 1 to 3, and X denotes an oxygen atom or sulfur atom).

Sont décrits un dérivé d'imidazolidinone représenté par la formule générale (1) et possédant une activité cholinergique (activité muscarine M1), ainsi que son sel d'addition d'acide pharmacologiquement acceptable, tous deux étant utiles pour traiter la démence sénile. Dans ladite formule, R représente alkyle inférieur éventuellement halogéné, etc.; R<1> et R<2> peuvent être identiques ou différents et chacun représente hydrogène ou alkyle inférieur; R<3> représente R<4>-(CH2)q-, R<4>-(CH2)q-C(=O)- ou bien R<5>-C=CCH2- (où R<4> représente alkyle inférieur éventuellement halogéné, etc., q vaut de 0 à 3, et R<5> représente hydrogène, etc.); m et n valent chacun de 0 à 3; p vaut de 1 à 3; et X représente oxygène ou soufre.

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