Methods and compositions for the assessment of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2673092

The present invention provides methods for the assessment of risk of developing acute coronary syndrome (ACS), arterial inflammation, or ACS-associated impaired vascular function, in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing ACS, arterial inflammation, or ACS-associated impaired vascular function. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided.

L'invention concerne des procédés d'évaluation du risque de développement du syndrome coronaire aigu (ACS), d'inflammations artérielles ou de troubles fonctionnels vasculaires associés au syndrome coronaire aigu, chez les fumeurs et les non-fumeurs, par analyse de polymorphismes génétiques. L'invention concerne également l'utilisation de polymorphismes génétiques dans l'évaluation du risque de développement du syndrome coronaire aigu, d'inflammations artérielles ou de troubles fonctionnels vasculaires associés au syndrome coronaire aigu, chez un sujet. L'invention concerne également des sondes et des amorces nucléotidiques, des ensembles et des microréseaux adaptés à une telle évaluation.

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