Polypeptides with therapeutic activity and methods of use

Details Polypeptides with therapeutic activity and methods of use Polypeptides with therapeutic activity and methods of use

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61L 2/00 (2006.01) A61L 2/18 (2006.01) A61P 31/02 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2397835

Polypeptides and methods of use including treating bacterial infection and/or endotoxemia, decreasing the amount of TNF-.alpha., inhibiting endothelial cell proliferation, inhibiting angiogenic-factor mediated inter-cellular adhesion molecule expression down-regulation, and inhibiting angiogenesis.

L'invention concerne des polypeptides et des procédés d'utilisation au moyen desquels on traite les infections bactériennes et/ou l'endotoxémie, on abaisse la quantité de TNF-.alpha., on inhibe la prolifération de cellules endothéliales, la régulation négative de l'expression des molécules d'adhésion intercellulaire induite par un facteur angiogénique, ainsi que l'angiogénèse.

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