Colon specific genes and proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2221798

Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptides and therapeutic uses of the antagonists are disclosed.

L'invention concerne des polypeptides de gènes spécifiques du colon humain, l'ADN (ARN) codant ces polypeptides ainsi qu'une procédure de production desdits polypeptides par des techniques de recombinaison. L'invention concerne également des procédés d'utilisation de tels polynucléotides ou polypeptides en tant que marqueurs de diagnostic dans le cas du cancer du colon et en tant qu'agent permettant de déterminer si le cancer du colon est métastasé. L'invention concerne également des anticorps spécifiques des polypeptides des gènes spécifiques du colon qui peuvent être uilisés pour cibler des cellules cancéreuses, ou comme composants d'un vaccin contre le cancer du colon. L'invention concerne en outre des procédés de criblage d'agonistes et d'antagonistes aux polypeptides ainsi que des utilisations thérapeutiques de ces antagonistes.

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