Treatment of autoimmune disease using oral tolerization...

Details Treatment of autoimmune disease using oral tolerization... Treatment of autoimmune disease using oral tolerization...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/21 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2185353

The invention is directed to methods for treating autoimmune diseases such as multiple sclerosis by orally administering a bystander antigen such as myelin basic protein or proteolipid protein in conjunction with a polypeptide having Type I interferon activity in such a manner as to induce oral tolerance to the bystander antigen resulting in suppression of the autoimmune response.

L'invention concerne des méthodes de traitement de maladies auto-immunes telles que la sclérose en plaques par l'administration par voie orale d'un antigène "bystander" tel qu'une protéine myélinique de base ou protéolipidique conjointement avec un polypeptide présentant l'activité de l'interféron de type I de sorte qu'une tolérance orale soit induite vis-à-vis de l'antigène "bystander" et entraîne la suppression de la réponse auto-immune.

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