Process for the preparation of perindopril

Details Process for the preparation of perindopril Process for the preparation of perindopril

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01)

Patent

CA 2562843

A process for preparing perindopril (III) or a pharmaceutically acceptable salt thereof, which process comprises a substituted benzyl ester of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (I) with N-[(S)- carbethoxybutyl]-(S)-alanine (II) where R represents a halo, C1-4 alkoxy or nitro substituent.

La présente invention a trait à un procédé pour la préparation de périndopril (III) ou un sel pharmaceutiquement acceptable de celui-ci ; le procédé comprenant un ester de benzyle substitué de l'acide carboxylique de (2S,3aS,7aS)-octahydroindole-2 (I) avec N-[(S)-carbethoxybutyl]-(S)-alanine (II), où R représente un substituant alcoxy en C¿1?-C¿4? ou nitro.

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