C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2647846
It is found that the blood half-life of an IgG antibody, which is a polypeptide having a FcRn binding region, can be controlled by a method comprising modifying a variable region residue of the IgG antibody exposed on the surface to thereby control the surface charge of the IgG antibody. It is confirmed that the antibody whose blood half-life is controlled by the method retains its activity practically. The method is widely applicable to any polypeptide having a FcRn binding region such as an IgG antibody, which can be recycled through a salvage pathway, regardless of the type of a target antigen.
On a trouvé que la demi-vie dans le sang d'un anticorps IgG, qui est un polypeptide comportant une région de liaison FcRn, peut se réguler selon un procédé consistant en une modification d'un reste de région variable de l'anticorps IgG apparent en surface de façon à réguler la charge superficielle de l'anticorps IgG. Il se confirme également que l'anticorps dont la demi-vie dans le sang est régulée selon ce procédé conserve pratiquement son activité. Ce procédé peut s'appliquer largement à n'importe quel polypeptide comportant une région de liaison FcRn telle qu'un anticorps IgG, qui peut se recycler par un chemin de sauvetage, quelque soit le type de l'antigène cible.
Igawa Tomoyuki
Tachibana Tatsuhiko
Tsunoda Hiroyuki
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
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