A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2537489
The present invention relates to the novel nucleic acid constructs, useful in nucleic acid vaccination protocols for the treatment and prophylaxis of MUC-1 expressing tumours. In particular the construct comprises a fusion between a heat shock protein gene HSP70, typically from Mycobacterium tuberculosis and MUC-1 or derivative thereof. The invention further provides pharmaceutical compositions comprising said constructs and proteins, particularly pharmaceutical compositions adapted for particle mediated delivery, methods for producing them, and their use in medicine, particularly in the treatment of MUC-1 expressing tumours.
La présente invention concerne des nouvelles constructions d'acides nucléiques utiles dans les protocoles de vaccination basés sur les acides nucléiques pour le traitement et la prévention de tumeurs exprimant MUC-1. Plus particulièrement, la construction présente une fusion entre un gène HSP70 de protéine de choc thermique, habituellement issu de Mycobacterium tuberculosis, et MUC-1 ou un dérivé correspondant. L'invention concerne en outre des compositions pharmaceutiques renfermant lesdites constructions et protéines, et notamment des compositions pharmaceutiques destinées à une administration à médiation particulaire, des méthodes pour leur production, ainsi que leur utilisation en médecine, notamment dans le traitement de tumeurs exprimant MUC-1.
Hamblin Paul Andrew
Rocha Del Cura Maria de Los Angeles
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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