Insulin-dependent yeast or fungi

Details Insulin-dependent yeast or fungi Insulin-dependent yeast or fungi

C - Chemistry, Metallurgy

12

N

C12N 15/17 (2006.01) C07K 14/62 (2006.01) C12N 1/14 (2006.01) C12N 15/01 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2146432

The present invention relates to newly created and isolated insulin-dependent mutant strains of yeast or fungi such as S. cerevisiae. The mutants grow on complex media of defined and undefined compositions. Optimal growth, morphology and viabil- ity of certain isolates demonstrate varying dependence upon supraphysiological concentrations of insulin. Other isolates are rela- tively insensitive to the same concentrations of insulin and can be maintained in the presence of the hormone for extended peri- ods of time without toxic effects. The invention also pertains to a method for detecting insulin secretagogues which employs the mutant yeast cells. Furthermore, the invention encompasses methods for the production of recombinant insulin employing the mutant yeasts as host cells.

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