C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/36 (2006.01) A61K 39/10 (2006.01)
Patent
CA 2645190
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
La présente invention concerne une souche mutée de Bordetella comprenant au moins un gène ptx muté, un gène dnt délété ou muté et un gène hétérologue ampG. La souche mutée atténuée de Bordetella peut être utilisée dans une composition immunogène ou un vaccin destiné au traitement ou à la prévention d'une infection par Bordetella. L'invention concerne de plus l'utilisation de la souche atténuée de Bordetella pour la fabrication d'un vaccin ou d'une composition immunogène, ainsi que des procédés permettant de protéger les mammifères contre une infection par Bordetella.
Bertout Julie
Debrie Anne-Sophie
Locht Camille
Mielcarek Nathalie
Raze Dominique
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur de Lille
Smart & Biggar
LandOfFree
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