Hydantoin-containing glucokinase activators

Details Hydantoin-containing glucokinase activators Hydantoin-containing glucokinase activators

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4166 (2006.01) A61P 43/00 (2006.01) C07D 401/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2407428

Hydantoin compounds of the formula: wherein R1 is a five-or-six-membered aromatic heterocyclic ring having one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which ring is unsubstituted or substituted with halo, amino, hydroxylamino, nitro, cyano, sulfonamido, lower alkyl, perfluoro lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-lower alkyl sulfonyl, lower alkyl sulfinyl, or-(R5)n-C(O)-OR6; R2 is a cycloalkyl ring containing from 5 to 7 carbon atoms; which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.

L'invention concerne des composés d'hydantoïne agissant comme activateurs de glucokinase pour augmenter la sécrétion d'insuline, d'où leur utilité dans le traitement de diabètes de type II.

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