Sustained release of peptides from pharmaceutical compositions

Details Sustained release of peptides from pharmaceutical compositions Sustained release of peptides from pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/70 (2006.01) A61K 38/00 (2006.01) A61K 38/22 (2006.01) A61K 38/25 (2006.01) A61K 38/28 (2006.01) A61K 38/29 (2006.01) A61K 38/31 (2006.01) A61M 5/142 (2006.01) A61J 1/00 (2006.01) A61K 47/26 (2006.01) A61M 5/315 (2006.01)

Patent

CA 2198917

The invention features a solid, non-particulate, sustained-release pharmaceutical composition for parenteral administration to a patient. The composition consists essentially of: (1) a soluble, gelable peptide salt, and (2) up to 30 percent by weight of a pharmaceutically acceptable, monomeric, soluble carrier, compounded into a solid cylindrical form, wherein the solid composition automatically forms a gel after interaction with the patient's bodily fluids, the gel releasing the peptide continuously within the patient over an extended period of at least three days.

L'invention concerne une composition pharmaceutique solide, non particulaire et à libération prolongée destinée à être administrée par voie parentérale à un patient. La composition comprend essentiellement: (1) un sel peptidique gélifiable soluble; et (2) jusqu'à 30 % en poids d'un véhicule monomère soluble et pharmaceutiquement acceptable, se présentant une forme galénique solide cylindrique, la composition solide formant automatiquement un gel après l'interaction avec les liquides biologiques du patient, le gel libérant le peptide en continu dans le corps du patient sur une période prolongée d'au moins trois jours.

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