C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61L 27/38 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2313808
Fibroblast cells are treated with a chemical inhibitor of protein kinase C such as staurosporine, in conjunction with functionally hypoxic micromass culture so as to be induced into chondrogenic differentiation. Such fibroblast- derived, chondrocyte-like cells may be seeded onto three-dimensional polymer scaffolds for use in the repair of articular cartilage lesions, and thus can obviate the need for invasive techniques to harvest autologous chondrocytes from a limited supply of existing articular cartilage, or to avoid the need for obtaining allogeneic chondrocytes from non-biocompatible donor tissues.
Des cellules fibroblastiques sont traitées avec un inhibiteur chimique de protéine kinase C, par exemple la staurosporine, conjointement à une culture de micromasse fonctionnellement hypoxique, de manière à être induites par chondrogenèse. Ces cellules de type chondrocytes dérivées des fibroblastes peuvent être implantées sur des structures polymères tridimensionnelles, destinées à être utilisées pour réparer des lésions du cartilage articulaire, ce qui permet d'éviter de recourir à des techniques invasives pour collecter des chondrocytes autologues à partir d'un cartilage auriculaire existant, ou d'avoir à obtenir des chondrocytes allogéniques à partir de tissus de prélèvement non biocompatibles.
Bhatnagar Rajendra S.
Nicoll Steven B.
Smart & Biggar
The Regents Of The University Of California
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