Process for producing either optically active n-substituted...

Details Process for producing either optically active n-substituted... Process for producing either optically active n-substituted...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12P 13/04 (2006.01)

Patent

CA 2481839

A process in which a racemic mixture of an N-substituted .szlig.-amino acid alkyl ester or N-substituted 2-homopipecolic acid ester represented by the general formula (I): (I) (wherein Ar, R1, R2, R3, R4, and R5 are as defined in the description) is subjected to selective hydrolysis of only either of the enantiomers in the presence of a hydrolase to yield an optically active, N- substituted ((R) or (S))-.szlig.-amino acid or optically active, N-substituted ((R) or (S))-2-homopipecolic acid represented by the general formula (II): (II) and simultaneously obtain the unreacted, optically active, N-substituted ((S) or (R))-.szlig.-amino acid alkyl ester or unreacted, optically active, N- substituted ((S) or (R))-2-homopipecolic acid ester represented by the general formula (III): (III) which has the absolute configuration opposite to that of the compound represented by the general formula (II).

L'invention concerne un procédé dans lequel le mélange racémique d'un ester alkylique d'acide .beta.-aminé N-substitué ou d'un ester d'acide 2-homopipécolique N-substitué représenté par la formule (I), (dans laquelle Ar, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans le descriptif), est soumis à une hydrolyse sélective d'un des énantiomères seulement en présence d'une hydrolase pour former un acide ((R) ou (S))-.beta.-aminé optiquement actif, un acide ((R) ou (S))-2-homopipécolique représenté par la formule générale (II) et obtenir simultanément l'ester alkylique d'acide ((S) ou (R ))-.beta.-aminé N-substitué, non réagi et optiquement actif, ou l'ester d'acide ((S) ou (R))-2-homopécolique N-substitué, non réagi et optiquement actif, représenté par la formule générale (III), dont la configuration est complètement opposée à celle du composés représenté par la formule générale (II).

Affiliated with

Also associated with

Rating

Process for producing either optically active n-substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing either optically active n-substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing either optically active n-substituted... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1729071