C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2374000
The present invention is related to the of soluble nephrin-like molecules expressed by pancreas and kidney and nucleic acid sequences encoding said nephrin-like molecules, including a human nephrin encoding cDNA, as well as binding substances, capable of specifically recognizing and binding said nephrin-like molecules. The molecules are useful for manufacturing means for diagnostic determination, screening susceptibility of, prophylactic and therapeutic treatment of diabetic and other nephropathies and of diabetes mellitus and other inflammatory and neoplastic pancreatic diseases. The invention is further characterized by the fact that the soluble nephrin-like molecules, binding substances specifically recognizing said soluble nephrin- like molecules can be used to make the diagnostic evaluation from a blood, serum and/or urine sample.
L'invention concerne des molécules de type néphrine solubles exprimées par le pancréas et les reins et des séquences d'acides nucléiques codant pour ces molécules de type néphrine, comprenant un ADNc codant pour une néphrine humaine ainsi que des substances de liaison capables de reconnaître et de lier de manière spécifique ces molécules de type néphrine. Ces molécules sont utiles pour fabriquer des moyens de détermination diagnostique, de susceptibilité au criblage, de traitements préventif et thérapeutique du diabète et d'autre néphropathies, du diabète sucré ainsi que d'autres maladies pancréatiques inflammatoires et néoplasiques. L'invention est caractérisée en ce que les molécules de type néphrine solubles et les subsistances de liaison permettant de reconnaître ces molécules de type néphrine solubles peuvent être utilisées lors de l'évaluation diagnostique à partir d'un prélèvement de sang, de sérum et/ou d'urine.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Glomega Inc. Oy
Holthofer Harry
LandOfFree
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