C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 31/712 (2006.01) A61P 35/00 (2006.01) C07H 19/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2745811
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Suppressor genes, in particular, by targeting natural antisense polynucleotides of Tumor Suppressor genes. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Tumor Suppressor genes.
La présente invention porte sur des oligonucléotides antisens qui modulent l'expression et/ou la fonction de gènes suppresseurs de tumeur, en particulier, en ciblant des polynucléotides antisens naturels de gènes suppresseurs de tumeur. L'invention porte également sur l'identification de ces oligonucléotides antisens et sur leur utilisation pour le traitement de maladies et de troubles associés à l'expression de gènes suppresseurs de tumeur.
Collard Joseph
Khorkova Sherman Olga
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Opko Curna Llc
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