Quinoline derivatives and use thereof as antitumor agents

Details Quinoline derivatives and use thereof as antitumor agents Quinoline derivatives and use thereof as antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 215/227 (2006.01)

Patent

CA 2456173

The invention provides compounds of formula (I) : Wherein Y is F, Cl, Br, methyl or methoxy ; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for preparing a compound of formula (1) , and therapeutic methods comprising administering a compound of formula (I) or a salt thereof to a mammal in need thereof.

L'invention concerne des composés de formule (I) dans laquelle Y représente un atome de F, Cl, Br, un groupe méthyle ou méthoxy, ainsi que des sels de ces composés, acceptables sur le plan pharmaceutique. Les composés sont efficaces en tant qu'antitumoraux. L'invention concerne aussi des compositions pharmaceutiques comprenant un composé de formule (I), ou un sel de ce composé, des intermédiaires utiles pour la préparation d'un composé de formule (1), ainsi que des méthodes thérapeutiques consistant à administrer un composé de formule (I), ou un sel de ce composé, à un mammifère les nécessitant.

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