Use of flavanolignanes for the preparation of medicaments...

Details Use of flavanolignanes for the preparation of medicaments... Use of flavanolignanes for the preparation of medicaments...

A - Human Necessities

61

K

A61K 31/35 (2006.01) A61K 31/335 (2006.01) A61K 31/357 (2006.01)

Patent

CA 2221753

The invention relates to the use of flavanolignanes such as silymarin, silybin, silidianin, silicristin, mixtures thereof, extracts and formulations containing them, in the therapy (and prophylaxis) of uterus, ovary and breast tumors. These flavanolignanes have already been used in therapy for the treatment of hepatopathias of different origin, and they surprisingly show a marked affinity to the estrogen receptors of type II and an antiproliferative activity on tumor cell lines of uterus, ovary and breast.

L'invention se rapporte à l'utilisation de flavanolignanes telles que silymarine, silybine, silidianine, silicristine, des mélanges de celles-ci, des extraits et des formulations les contenant, dans la thérapie (et la prophylaxie) des tumeurs de l'utérus, des ovaires et des seins. Ces flavanolignanes ont déjà été utilisées en thérapie pour traiter des hépatopathies d'origine différente, et présentent, de façon surprenante, une affinité marquée aux récepteurs d'oestrogènes de type II et une activité antiproliférative sur les lignes cellulaires tumorales de l'utérus des ovaires et des seins.

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