Metastatin and hyaluronate binding proteins and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01N 37/18 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) C07K 1/00 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2324624

Compositions comprising hyaluronate (HA) binding proteins and peptides are provided as well as methods of using the HA binding proteins and peptides to inhibit cancer and angiogenesis-dependent diseases. In a preferred embodiment, the hyaluronic acid binding link module is metastatin protein, an approximately 38 kDa inhibitor of tumor growth and tumor metastasis.

La présente invention concerne des compositions renfermant des peptides et des protéines de fixation d'hyaluronate (HA) ainsi que leurs procédés d'utilisations dans l'inhibition du cancer et des maladies liées à l'angiogenèse. Dans un mode préféré de réalisation, le module de liaison fixant l'acide hyaluronique est une protéine métastatine d'environ 38 kDA, inhibant la croissance tumorale et les métastases tumorales.

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